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Novel Repression of Kcc2 Transcription by REST–RE-1 Controls Developmental Switch in Neuronal Chloride

Transcriptional upregulation of Kcc2b, the gene variant encoding the major isoform of the KCC2 chloride transporter, underlies a rapid perinatal decrease in intraneuronal chloride concentration (chloride shift), which is necessary for GABA to act inhibitory. Here we identify a novel repressor elemen...

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書誌詳細
主要な著者: Yeo, Michele, Berglund, Ken, Augustine, George, Liedtke, Wolfgang
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833346/
https://ncbi.nlm.nih.gov/pubmed/19923298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2934-09.2009
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