GADD45β Enhances Col10a1 Transcription via the MTK1/MKK3/6/p38 Axis and Activation of C/EBPβ-TAD4 in Terminally Differentiating Chondrocytes

GADD45β (growth arrest- and DNA damage-inducible) interacts with upstream regulators of the JNK and p38 stress response kinases. Previously, we reported that the hypertrophic zone of the Gadd45β(−/−) mouse embryonic growth plate is compressed, and expression of type X collagen (Col10a1) and matrix m...

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Detalhes bibliográficos
Main Authors: Tsuchimochi, Kaneyuki, Otero, Miguel, Dragomir, Cecilia L., Plumb, Darren A., Zerbini, Luiz F., Libermann, Towia A., Marcu, Kenneth B., Komiya, Setsuro, Ijiri, Kosei, Goldring, Mary B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832989/
https://ncbi.nlm.nih.gov/pubmed/20048163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038638
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