G Proteins in Reverse Mode: RECEPTOR-MEDIATED GTP RELEASE INHIBITS G PROTEIN AND EFFECTOR FUNCTION

Active G protein-coupled receptors activate heterotrimeric Gαβγ proteins by catalyzing the exchange of GDP by GTP at the Gα subunit. A paradoxical attenuation of G protein-activated inwardly rectifying potassium channels (GIRK) upon stimulation of native cells with high concentrations of agonist is...

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Hlavní autoři: Hommers, Leif G., Klenk, Christoph, Dees, Christian, Bünemann, Moritz
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832974/
https://ncbi.nlm.nih.gov/pubmed/20075078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.015388
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