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Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme

BACKGROUND: Glioblastoma multiforme (GBM), a highly invasive and vascular cancer, responds poorly to conventional cytotoxic therapy. Integrins, widely expressed in GBM and tumor vasculature, mediate cell survival, migration and angiogenesis. Cilengitide is a potent αvβ3 and αvβ5 integrin inhibitor....

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Main Authors: Reardon, David A, Nabors, L Burt, Stupp, Roger, Mikkelsen, Tom
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832832/
https://ncbi.nlm.nih.gov/pubmed/18616418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/13543784.17.8.1225
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