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Peptide-Catalyzed Kinetic Resolution of Formamides and Thioformamides as an Entry to Nonracemic Amines

[Image: see text] We report a fundamentally unique approach to the catalytic kinetic resolution of amine-derivatives based on formamide and thioformamide substrates. Readily accessible histidine-containing peptides mediate the kinetic resolutions with as little as 5 mol% of the catalyst. Selectivity...

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Hlavní autoři: Fowler, Brandon S., Mikochik, Peter J., Miller, Scott J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832744/
https://ncbi.nlm.nih.gov/pubmed/20158213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9107897
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