The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl-terminus

BACKGROUND & AIMS: The APC tumor suppressor is well known for its ability to regulate Wnt signaling through mediation of β-catenin levels in the cell. Transient over-expression of the tumor suppressor gene APC in colon cancer cells prevents entry into S-phase of the cell cycle, a phenotype only...

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Bibliografische gegevens
Hoofdauteurs: Qian, Jiang, Sarnaik, Amod A., Bonney, Tera M., Keirsey, Jeremy, Combs, Kelly A., Steigerwald, Kira, Acharya, Samir, Behbehani, Gregory K., Barton, Michelle C., Lowy, Andy M., Groden, Joanna
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832605/
https://ncbi.nlm.nih.gov/pubmed/18474248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.03.074
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