Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation

p32/gC1qR/C1QBP/HABP1 is a mitochondrial/cell surface protein overexpressed in certain cancer cells. Here we show that knocking down p32 expression in human cancer cells strongly shifts their metabolism from oxidative phosphorylation (OXPHOS) to glycolysis. The p32 knockdown cells exhibited reduced...

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Bibliografiske detaljer
Main Authors: Fogal, Valentina, Richardson, Adam D., Karmali, Priya P., Scheffler, Immo E., Smith, Jeffrey W., Ruoslahti, Erkki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832503/
https://ncbi.nlm.nih.gov/pubmed/20100866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01101-09
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