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E2F4 cooperates with pRB in the development of extra-embryonic tissues
The retinoblastoma gene, RB-1, was the first identified tumor suppressor. Rb(−/−) mice die in mid-gestation with defects in proliferation, differentiation and apoptosis. The activating E2F transcription factors, E2F1-3, contribute to these embryonic defects, indicating that they are key downstream t...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2832217/ https://ncbi.nlm.nih.gov/pubmed/19433082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2009.05.541 |
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