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Total Synthesis of (+)-Fendleridine (Aspidoalbidine) and (+)-1-Acetylaspidoalbidine

A total synthesis of the Aspidosperma alkaloids (+)-fendleridine (1) and (+)-1-acetylaspidoalbidine (2) is detailed, providing access to both enantiomers of the natural products and establishing their absolute configuration. Central to the synthetic approach is a powerful intramolecular [4 + 2]/[3 +...

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Autors principals: Campbell, Erica L., Zuhl, Andrea M., Liu, Christopher M., Boger, Dale L.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832086/
https://ncbi.nlm.nih.gov/pubmed/20148585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja908819q
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