Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone

Niemann-Pick C disease (NPC) is an autosomal recessive neurodegenerative disorder caused by the abnormal function of NPC1 or NPC2 proteins, leading to an accumulation of unesterified cholesterol and glycosphingolipids (GSLs) in the lysosomes. The mechanisms underlying the pathophysiology in NPC dise...

Full description

Saved in:
Bibliographic Details
Main Authors: Zampieri, Stefania, Mellon, Synthia H, Butters, Terry D, Nevyjel, Marco, Covey, Douglas F, Bembi, Bruno, Dardis, Andrea
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2009
Subjects:
Molecular Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832077/
https://ncbi.nlm.nih.gov/pubmed/18774957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00493.x
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items