In Vitro Metabolic and Mitogenic Signaling of Insulin Glargine and Its Metabolites

BACKGROUND: Insulin glargine (Lantus®) is a long-acting basal insulin analog that demonstrates effective day-long glycemic control and a lower incidence of hypoglycemia than NPH insulin. After subcutaneous injection insulin glargine is partly converted into the two main metabolites M1 ([Gly(A21)]ins...

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Main Authors: Sommerfeld, Mark R., Müller, Günter, Tschank, Georg, Seipke, Gerhard, Habermann, Paul, Kurrle, Roland, Tennagels, Norbert
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832019/
https://ncbi.nlm.nih.gov/pubmed/20209060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009540
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