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Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation
BACKGROUND: MRE11 is an important nuclease which functions in the end-resection step of homologous recombination (HR) repair of DNA double-strand breaks (DSBs). As MRE11-deficient ATLD cells exhibit hyper radio-sensitivity and impaired DSB repair, MRE11 inhibitors could possibly function as potent r...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2831819/ https://ncbi.nlm.nih.gov/pubmed/20144237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-34 |
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