Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation

BACKGROUND: MRE11 is an important nuclease which functions in the end-resection step of homologous recombination (HR) repair of DNA double-strand breaks (DSBs). As MRE11-deficient ATLD cells exhibit hyper radio-sensitivity and impaired DSB repair, MRE11 inhibitors could possibly function as potent r...

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Détails bibliographiques
Auteurs principaux: Kobayashi, Junya, Kato, Akihiro, Ota, Yosuke, Ohba, Reiko, Komatsu, Kenshi
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2010
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831819/
https://ncbi.nlm.nih.gov/pubmed/20144237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-34
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