Finding the missing heritability of complex diseases

Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture. Most variants identified so far confer relatively small increments in risk, and explain only a small pr...

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Autors principals: Manolio, Teri A., Collins, Francis S., Cox, Nancy J., Goldstein, David B., Hindorff, Lucia A., Hunter, David J., McCarthy, Mark I., Ramos, Erin M., Cardon, Lon R., Chakravarti, Aravinda, Cho, Judy H., Guttmacher, Alan E., Kong, Augustine, Kruglyak, Leonid, Mardis, Elaine, Rotimi, Charles N., Slatkin, Montgomery, Valle, David, Whittemore, Alice S., Boehnke, Michael, Clark, Andrew G., Eichler, Evan E., Gibson, Greg, Haines, Jonathan L., Mackay, Trudy F. C., McCarroll, Steven A., Visscher, Peter M.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831613/
https://ncbi.nlm.nih.gov/pubmed/19812666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08494
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