Finding the missing heritability of complex diseases

Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture. Most variants identified so far confer relatively small increments in risk, and explain only a small pr...

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Detalhes bibliográficos
Main Authors: Manolio, Teri A., Collins, Francis S., Cox, Nancy J., Goldstein, David B., Hindorff, Lucia A., Hunter, David J., McCarthy, Mark I., Ramos, Erin M., Cardon, Lon R., Chakravarti, Aravinda, Cho, Judy H., Guttmacher, Alan E., Kong, Augustine, Kruglyak, Leonid, Mardis, Elaine, Rotimi, Charles N., Slatkin, Montgomery, Valle, David, Whittemore, Alice S., Boehnke, Michael, Clark, Andrew G., Eichler, Evan E., Gibson, Greg, Haines, Jonathan L., Mackay, Trudy F. C., McCarroll, Steven A., Visscher, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831613/
https://ncbi.nlm.nih.gov/pubmed/19812666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08494
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