Overexpression of Dimethylarginine Dimethylaminohydrolase Protects against Cerebral Vascular Effects of Hyperhomocysteinemia

BACKGROUND: Hyperhomocysteinemia is a cardiovascular risk factor that is associated with the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA). Using mice transgenic for overexpression of the ADMA-hydrolyzing enzyme dimethylarginine dimethylaminohydrolase-1 (DDAH1), we tested the hy...

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Detalhes bibliográficos
Main Authors: Rodionov, Roman N., Dayoub, Hayan, Lynch, Cynthia M., Wilson, Katina M., Stevens, Jeff W., Murry, Daryl J., Kimoto, Masumi, Arning, Erland, Bottiglieri, Teodoro, Cooke, John P., Baumbach, Gary L., Faraci, Frank M., Lentz, Steven R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831416/
https://ncbi.nlm.nih.gov/pubmed/20019334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.200360
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