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Reexpression of hSNF5 in malignant rhabdoid tumor cell lines causes cell cycle arrest through a p21(CIP1/WAF1)-dependent mechanism

Loss of hSNF5 function is usually observed in malignant rhabdoid tumor (MRT), a highly aggressive pediatric neoplasm. Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G(1) cell cycle arrest with p16(INK4A), p21(CIP1/WAF1) and cyclin D(1) playing key roles in MRT cell g...

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Detalhes bibliográficos
Main Authors: Kuwahara, Yasumichi, Charboneau, Aubri, Knudsen, Erik S., Weissman, Bernard E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831128/
https://ncbi.nlm.nih.gov/pubmed/20179200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1922
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