An Adenoviral Vaccine Encoding Full-Length Inactivated Human HER2 Exhibits Potent Immunogenicty and Enhanced Therapeutic Efficacy Without Oncogenicity

PURPOSE: Overexpression of the breast cancer oncogene HER2 correlates with poor survival. Current HER2-directed therapies confer limited clinical benefits and most patients experience progressive disease. Because refractory tumors remain strongly HER2+, vaccine approaches targeting HER2 have therape...

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Autores principales: Hartman, Zachary, Wei, Junping, Osada, Takuya, Glass, Oliver, Lei, Gangjun, Yang, Xiao-Yi, Peplinski, Sharon, Kim, Dong-Wan, Xia, Wenle, Spector, Neil, Marks, Jeffrey, Barry, William, Hobeika, Amy, Devi, Gayathri, Amalfitano, Andrea, Morse, Michael A., Lyerly, H. Kim, Clay, Timothy M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831125/
https://ncbi.nlm.nih.gov/pubmed/20179231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2549
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