Nalaganje...
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
The Ras-dependent Raf/MEK/ERK1/2 mitogen-activated protein (MAP) kinase signaling pathway is a major regulator of cell proliferation and survival. Not surprisingly, hyperactivation of this pathway is frequently observed in human malignancies as a result of aberrant activation of receptor tyrosine ki...
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2830959/ https://ncbi.nlm.nih.gov/pubmed/20149254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-3-8 |
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