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Reassessing the role of HLA-DRB3 T cell responses: Evidence for significant expression and complementary antigen presentation

In humans, several HLA-DRB loci (DRB1/3/4/5) encode diverse beta-chains which pair with alpha-chains to form DR molecules on the surface of APC. While DRB1 and DRB5 have been extensively studied, the role of DRB3/4 products of DR52/DR53 haplotypes has been largely neglected. To clarify the relative...

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Main Authors: Faner, Rosa, James, Eddie, Huston, Laurie, Pujol-Borrel, Ricardo, Kwok, William W, Juan, Manel
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830809/
https://ncbi.nlm.nih.gov/pubmed/19830726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939225
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