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Rapid reprogramming of haemoglobin structure-function exposes multiple dual-antimicrobial potencies

The intrinsic cytotoxicity of cell-free haemoglobin (Hb) has hampered the development of reliable Hb-based blood substitutes for over seven decades. Notably, recent evidence shows that the Hb deploys this cytotoxic attack against invading microbes, albeit, through an unknown mechanism. Here, we unra...

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Detalhes bibliográficos
Main Authors: Du, Ruijuan, Ho, Bow, Ding, Jeak Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830699/
https://ncbi.nlm.nih.gov/pubmed/20019665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.380
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