The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation

αB-Crystallin is a small heat-shock protein (sHsp) that is colocalized with α-synuclein (αSyn) in Lewy bodies—the pathological hallmarks of Parkinson's disease—and is an inhibitor of αSyn amyloid fibril formation in an ATP-independent manner in vitro. We have investigated the mechanism underlyi...

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Bibliografiske detaljer
Main Authors: Waudby, Christopher A., Knowles, Tuomas P.J., Devlin, Glyn L., Skepper, Jeremy N., Ecroyd, Heath, Carver, John A., Welland, Mark E., Christodoulou, John, Dobson, Christopher M., Meehan, Sarah
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2010
Fag:
Protein
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830463/
https://ncbi.nlm.nih.gov/pubmed/20197038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.10.056
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