Loss of the Actin Remodeler Eps8 Causes Intestinal Defects and Improved Metabolic Status in Mice

BACKGROUND: In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that knockout mice for Eps8, a regulator of actin...

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Main Authors: Tocchetti, Arianna, Ekalle Soppo, Charlotte Blanche, Zani, Fabio, Bianchi, Fabrizio, Gagliani, Maria Cristina, Pozzi, Benedetta, Rozman, Jan, Elvert, Ralf, Ehrhardt, Nicole, Rathkolb, Birgit, Moerth, Corinna, Horsch, Marion, Fuchs, Helmut, Gailus-Durner, Valérie, Beckers, Johannes, Klingenspor, Martin, Wolf, Eckhard, de Angelis, Martin Hrabé, Scanziani, Eugenio, Tacchetti, Carlo, Scita, Giorgio, Di Fiore, Pier Paolo, Offenhäuser, Nina
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830459/
https://ncbi.nlm.nih.gov/pubmed/20209148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009468
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