High Density DNA Array Analysis Reveals Distinct Genomic Profiles in a Subset of Gastrointestinal Stromal Tumors

Gastrointestinal stromal tumors (GISTs) generally harbor activating mutations in KIT or PDGFRA. Mutations in these receptor tyrosine kinases lead to dysregulation of downstream signaling pathways that contribute to GIST pathogenesis. GISTs with KIT or PDGFRA mutations also undergo secondary cytogene...

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Autori principali: Belinsky, Martin G., Skorobogatko, Yuliya V., Rink, Lori, Pei, Jianming, Cai, Kathy Q., Vanderveer, Lisa A., Riddell, David, Merkel, Erin, Tarn, Chi, Eisenberg, Burton L., von Mehren, Margaret, Testa, Joseph R., Godwin, Andrew K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830286/
https://ncbi.nlm.nih.gov/pubmed/19585585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.20689
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