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Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors
A subset of gastrointestinal stromal tumors (GISTs) lack gain-of-function mutations in c-KIT and PDGFRα. These so-called wild-type (WT) GISTs tend to be less responsive to imatinib-based therapies and have a poor prognosis. We identified amplification of IGF1R in a SNP analysis of GIST and thus stud...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2448846/ https://ncbi.nlm.nih.gov/pubmed/18550829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803383105 |
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