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Modeling of replicative senescence in hematopoietic development

Hematopoietic stem cells (HSC) give rise to an enormous number of blood cells throughout our life. In contrast their number of cell divisions preceding senescence is limited underin vitro culture conditions. Here we consider the question whether HSC can rejuvenate indefinitely or if the number of ce...

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Autors principals: Marciniak-Czochra, Anna, Stiehl, Thomas, Wagner, Wolfgang
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830082/
https://ncbi.nlm.nih.gov/pubmed/20195386
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