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HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage
Histone deacetylase 1 (HDAC1) is a nuclear enzyme involved in transcriptional repression. We report here that cytosolic HDAC1 is detected in damaged axons in brains of human patients with Multiple Sclerosis and of mice with cuprizone-induced demyelination, ex vivo models of demyelination and in cult...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2829989/ https://ncbi.nlm.nih.gov/pubmed/20037577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2471 |
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