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StarD4-mediated Translocation of 7-Hydroperoxycholesterol to Isolated Mitochondria: Deleterious Effects and Implications for Steroidogenesis Under Oxidative Stress Conditions
StAR family proteins, including StarD4, play a key role in steroidogenesis by transporting cholesterol (Ch) into mitochondria for conversion to pregnenolone. Using a model system consisting of peroxidized cholesterol (7α-OOH)-containing liposomes as donors, we showed that human recombinant StarD4 ac...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2829839/ https://ncbi.nlm.nih.gov/pubmed/20059974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.12.165 |
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