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Hexokinase II Detachment from the Mitochondria Potentiates Cisplatin Induced Cytotoxicity through a Caspase-2 dependent Mechanism
Cancer cells are frequently glycolytic and over-express hexokinase II (HXK II). In cancer cells, the majority of hexokinase II is localized to the mitochondria through interaction with the voltage dependent anion channel (VDAC). Disruption in the binding of hexokinase II to the mitochondria has been...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2829766/ https://ncbi.nlm.nih.gov/pubmed/19770592 |
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