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Substrate Specificity Combined with Stereopromiscuity in Glutathione Transferase A4-4-dependent Metabolism of 4-Hydroxynonenal

Conjugation to glutathione (GSH) by glutathione transferase A4-4 (GSTA4-4) is a major route of elimination for the lipid peroxidation product 4-hydroxynonenal (HNE), a toxic compound that contributes to numerous diseases. Both enantiomers of HNE are presumed to be toxic, and GSTA4-4 has negligible s...

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Detalhes bibliográficos
Main Authors: Balogh, Larissa M., Le Trong, Isolde, Kripps, Kimberly A., Shireman, Laura M., Stenkamp, Ronald E., Zhang, Wei, Mannervik, Bengt, Atkins, William M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829664/
https://ncbi.nlm.nih.gov/pubmed/20085333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902038u
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