IL-1β Suppresses the Formation of Osteoclasts by Increasing OPG Production via an Autocrine Mechanism Involving Celecoxib-Related Prostaglandins in Chondrocytes

Elevated interleukin (IL)-1 concentrations in synovial fluid have been implicated in joint bone and cartilage destruction. Previously, we showed that IL-1β stimulated the expression of prostaglandin (PG) receptor EP4 via increased PGE(2) production. However, the effect of IL-1β on osteoclast formati...

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Detalhes bibliográficos
Main Authors: Watanabe, Yusuke, Namba, Aki, Aida, Yukiko, Honda, Kazuhiro, Tanaka, Hideki, Suzuki, Naoto, Matsumura, Hideo, Maeno, Masao
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829618/
https://ncbi.nlm.nih.gov/pubmed/20204061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/308596
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