Osteoclast Precursor Interaction with Bone Matrix Induces Osteoclast Formation Directly by an Interleukin-1-mediated Autocrine Mechanism

Interleukin-1 (IL-1) and tumor necrosis factor (TNF) mediate bone resorption in a variety of diseases affecting bone. Like TNF, IL-1 is secreted by osteoclast precursors (OCPs), but unlike TNF, it does not induce osteoclast formation directly from OCPs in vitro. TNF induces IL-1 expression and activ...

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Detalhes bibliográficos
Main Authors: Yao, Zhenqiang, Xing, Lianping, Qin, Chunlin, Schwarz, Edward M., Boyce, Brendan F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442286/
https://ncbi.nlm.nih.gov/pubmed/18250170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M706415200
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