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Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines
BACKGROUND: The histamine receptor-1 (H1)-antagonist, loratadine has been shown to inhibit growth of human colon cancer xenografts in part due to cell cycle arrest in G2/M. Since this is a radiation sensitive phase of the cell cycle, we sought to determine if loratadine modifies radiosensitivity in...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2829588/ https://ncbi.nlm.nih.gov/pubmed/20128919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-5-8 |
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