Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines

BACKGROUND: The histamine receptor-1 (H1)-antagonist, loratadine has been shown to inhibit growth of human colon cancer xenografts in part due to cell cycle arrest in G2/M. Since this is a radiation sensitive phase of the cell cycle, we sought to determine if loratadine modifies radiosensitivity in...

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Hauptverfasser: Soule, Benjamin P, Simone, Nicole L, DeGraff, William G, Choudhuri, Rajani, Cook, John A, Mitchell, James B
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829588/
https://ncbi.nlm.nih.gov/pubmed/20128919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-5-8
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