Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly

BACKGROUND: Important functional connections within the “default mode network” (DMN) are disrupted in Alzheimer’s disease (AD), likely from amyloid-beta (Aβ) plaque-associated neuronal toxicity. Here we sought to determine if pathological effects of Aβ amyloid plaques could be seen even in the absen...

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Bibliografiske detaljer
Main Authors: Sheline, Yvette I., Raichle, Marcus E., Snyder, Abraham Z., Morris, John C., Head, Denise, Wang, Suzhi, Mintun, Mark A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829379/
https://ncbi.nlm.nih.gov/pubmed/19833321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2009.08.024
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