Factors Determining the Risk of Inadvertent Retroviral Transduction of Male Germ Cells After In Utero Gene Transfer in Sheep

The possibility of permanent genetic changes to the germline is central to the bioethics of in utero gene therapy (IUGT) because of the concern of inadvertent potentially deleterious alterations to the gene pool. Despite presumed protection of the male germline due to early germ cell (GC) compartmen...

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Bibliografiske detaljer
Main Authors: Park, Paul J., Colletti, Evan, Ozturk, Ferhat, Wood, Josh A., Tellez, Joe, Almeida-Porada, Graça, Porada, Christopher D.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2009
Fag:
Scientific Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829302/
https://ncbi.nlm.nih.gov/pubmed/19301473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2007.120
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