Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element

How tumour suppressor p53 bifurcates cell cycle arrest and apoptosis and executes these distinct pathways is not clearly understood. We show that BAX and PUMA promoters harbour an identical MAR element and are transcriptional targets of SMAR1. On mild DNA damage, SMAR1 selectively represses BAX and...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Sinha, Surajit, Malonia, Sunil Kumar, Mittal, Smriti P K, Singh, Kamini, Kadreppa, Sreenath, Kamat, Rohan, Mukhopadhyaya, Robin, Pal, Jayanta K, Chattopadhyay, Samit
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829167/
https://ncbi.nlm.nih.gov/pubmed/20075864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.395
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller