Stabilization of SMAR1 mRNA by PGA2 involves a stem–loop structure in the 5′ UTR

Prostaglandins are anticancer agents known to inhibit tumor cell proliferation both in vitro and in vivo by affecting the mRNA stability. Here we report that a MAR-binding protein SMAR1 is a target of Prostaglandin A2 (PGA2) induced growth arrest. We identify a regulatory mechanism leading to stabil...

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Detalhes bibliográficos
Main Authors: Pavithra, Lakshminarasimhan, Rampalli, Shravanti, Sinha, Surajit, Sreenath, Kadreppa, Pestell, Richard G., Chattopadhyay, Samit
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2094063/
https://ncbi.nlm.nih.gov/pubmed/17726044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm649
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