Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element

How tumour suppressor p53 bifurcates cell cycle arrest and apoptosis and executes these distinct pathways is not clearly understood. We show that BAX and PUMA promoters harbour an identical MAR element and are transcriptional targets of SMAR1. On mild DNA damage, SMAR1 selectively represses BAX and...

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Autori principali: Sinha, Surajit, Malonia, Sunil Kumar, Mittal, Smriti P K, Singh, Kamini, Kadreppa, Sreenath, Kamat, Rohan, Mukhopadhyaya, Robin, Pal, Jayanta K, Chattopadhyay, Samit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829167/
https://ncbi.nlm.nih.gov/pubmed/20075864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.395
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