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FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling
FANCM binds and remodels replication fork structures in vitro. We report that in vivo, FANCM controls DNA chain elongation in an ATPase-dependent manner. In the presence of replication inhibitors that do not damage DNA, FANCM counteracts fork movement, possibly by remodelling fork structures. Conver...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2829158/ https://ncbi.nlm.nih.gov/pubmed/20010692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.371 |
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