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Her2 Activates NF-κB and Induces Invasion Through the Canonical Pathway Involving IKKα
The membrane bound receptor tyrosine kinase Her2 is overexpressed in approximately 30% of human breast cancers which correlates with poor prognosis. Her2-induced signaling pathways include MAPK and PI3K/Akt, of which the latter has been shown to be critical for Her2(+) breast cancer cell growth and...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2829103/ https://ncbi.nlm.nih.gov/pubmed/19946332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.410 |
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