Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells

Productive cell migration requires the spatiotemporal coordination of cell adhesion, membrane protrusion, and actomyosin-mediated contraction. Integrins, engaged by the extracellular matrix (ECM), nucleate the formation of adhesive contacts at the cell's leading edge(s), and maturation of nasce...

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Bibliographic Details
Main Authors: Cirit, Murat, Krajcovic, Matej, Choi, Colin K., Welf, Erik S., Horwitz, Alan F., Haugh, Jason M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829041/
https://ncbi.nlm.nih.gov/pubmed/20195494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000688
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