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Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility

Animal cell migration is a complex process characterized by the coupling of adhesion, cytoskeletal, and signaling dynamics. Here we model local protrusion of the cell edge as a function of the load-bearing properties of integrin-based adhesions, actin polymerization fostered by adhesion-mediated sig...

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Detalles Bibliográficos
Main Authors: Welf, Erik S., Johnson, Heath E., Haugh, Jason M.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861089/
https://ncbi.nlm.nih.gov/pubmed/24152734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-06-0311
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