Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4(DCAF1) in the Nucleus

Current models imply that the FERM domain protein Merlin, encoded by the tumor suppressor NF2, inhibits mitogenic signaling at or near the plasma membrane. Here, we show that the closed, growth inhibitory form of Merlin accumulates in the nucleus, binds to the E3 ubiquitin ligase CRL4(DCAF1), and su...

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Detalhes bibliográficos
Main Authors: Li, Wei, You, Liru, Cooper, Jonathan, Schiavon, Gaia, Pepe-Caprio, Angela, Zhou, Lu, Ishii, Ryohei, Giovannini, Marco, Hanemann, C. Oliver, Long, Stephen B., Erdjument-Bromage, Hediye, Zhou, Pengbo, Tempst, Paul, Giancotti, Filippo G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828953/
https://ncbi.nlm.nih.gov/pubmed/20178741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.01.029
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