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Activation of Slo2.1 channels by niflumic acid

Slo2.1 channels conduct an outwardly rectifying K(+) current when activated by high [Na(+)](i). Here, we show that gating of these channels can also be activated by fenamates such as niflumic acid (NFA), even in the absence of intracellular Na(+). In Xenopus oocytes injected with <10 ng cRNA, het...

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Autores principales: Dai, Li, Garg, Vivek, Sanguinetti, Michael C.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828905/
https://ncbi.nlm.nih.gov/pubmed/20176855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200910316
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