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Identification of the Intracellular Na(+) Sensor in Slo2.1 Potassium Channels

Slo2 potassium channels have a very low open probability under normal physiological conditions, but are readily activated in response to an elevated [Na(+)](i) (e.g. during ischemia). An intracellular Na(+) coordination motif (DX(R/K)XXH) was previously identified in Kir3.2, Kir3.4, Kir5.1, and Slo2...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Thomson, Steven J., Hansen, Angela, Sanguinetti, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505520/
https://ncbi.nlm.nih.gov/pubmed/25903137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.653089
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