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Cold denaturation of monoclonal antibodies

The susceptibility of monoclonal antibodies (mAbs) to undergo cold denaturation remains unexplored. In this study, the phenomenon of cold denaturation was investigated for a mAb, mAb1, through thermodynamic and spectroscopic analyses. tryptophan fluorescence and circular dichroism (CD) spectra were...

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Autores principales: Lazar, Kristi L, Patapoff, Thomas W, Sharma, Vikas K
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828577/
https://ncbi.nlm.nih.gov/pubmed/20093856
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