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Targeted Inhibition of the Complement Alternative Pathway with Complement Receptor 2 and Factor H Attenuates Collagen Antibody-Induced Arthritis in Mice

The alternative pathway (AP) of complement is required for the induction of collagen Ab-induced arthritis (CAIA) in mice. The objective of this study was to examine the effect of a recombinant AP inhibitor containing complement receptor 2 and factor H (CR2-fH) on CAIA in mice. CR2 binds to tissue-fi...

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Detalhes bibliográficos
Main Authors: Banda, Nirmal K., Levitt, Brandt, Glogowska, Magdalena J., Thurman, Joshua M., Takahashi, Kazue, Stahl, Gregory L., Tomlinson, Stephen, Arend, William P., Holers, V. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828354/
https://ncbi.nlm.nih.gov/pubmed/19828624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901826
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