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Protein secondary structure appears to be robust under in silico evolution while protein disorder appears not to be

Motivation: The mutation of amino acids often impacts protein function and structure. Mutations without negative effect sustain evolutionary pressure. We study a particular aspect of structural robustness with respect to mutations: regular protein secondary structure and natively unstructured (intri...

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Bibliografski detalji
Glavni autori: Schaefer, Christian, Schlessinger, Avner, Rost, Burkhard
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828120/
https://ncbi.nlm.nih.gov/pubmed/20081223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btq012
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