Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas

Transformation of epithelial cells is associated with loss of cell polarity, which includes alterations in cell morphology as well as changes in the complement of plasma membrane proteins. Rab proteins regulate polarized trafficking to the cell membrane and therefore represent potential regulators o...

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Autores principales: Nam, Ki Taek, Lee, Hyuk-Joon, Smith, J. Joshua, Lapierre, Lynne A., Kamath, Vidya P., Chen, Xi, Aronow, Bruce J., Yeatman, Timothy J., Bhartur, Sheela G., Calhoun, Benjamin C., Condie, Brian, Manley, Nancy R., Beauchamp, R. Daniel, Coffey, Robert J., Goldenring, James R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827957/
https://ncbi.nlm.nih.gov/pubmed/20197623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40728
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