Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas

Transformation of epithelial cells is associated with loss of cell polarity, which includes alterations in cell morphology as well as changes in the complement of plasma membrane proteins. Rab proteins regulate polarized trafficking to the cell membrane and therefore represent potential regulators o...

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Главные авторы: Nam, Ki Taek, Lee, Hyuk-Joon, Smith, J. Joshua, Lapierre, Lynne A., Kamath, Vidya P., Chen, Xi, Aronow, Bruce J., Yeatman, Timothy J., Bhartur, Sheela G., Calhoun, Benjamin C., Condie, Brian, Manley, Nancy R., Beauchamp, R. Daniel, Coffey, Robert J., Goldenring, James R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2010
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827957/
https://ncbi.nlm.nih.gov/pubmed/20197623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40728
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